2024

K. Iwamori, K. Kubota, K. Kodama, L. Zhang, A. Kubo, H. Kokubo, T. Akimoto, S-I. Fukada. Decreased number of satellite cells-derived myonuclei in both fast- and slow-twitch muscles in HeyL-KO mice during voluntary running exercise. Skeletal Muscle, in press

K. Yanagawa, A. Kuma, M. Hamasaki, S. Kita, T. Yamamuro, K. Nishino, S. Nakamura, H. Omori, T. Kaminishi, S. Oikawa, Y. Kato, R. Edahiro, R. Kawagoe, T. Taniguchi, Y. Tanaka, T. Shima, K. Tabata, M. Iwatani, N. Bekku, R. Hanayama, Y. Okada, T. Akimoto, H. Kosako, A. Takahashi, I. Shimomura, Y. Sakata, T. Yoshimori. The Rubicon-WIPI axis regulates exosome biogenesis during aging. Nature Cell Biol, in press

Y. Akama, E. J. Park, N. Satoh-Takayama, A. Ito, E. Kawamoto, A. Gaowa, S. Oikawa, Y. Nakamori, T. Yamaguchi, M. Saito, S. Inoue, T. Akimoto, H. Imai, M. Shimaoka. Roles of programmed death-1 and muscle innate lymphoid cell-derived IL-13 in sepsis-induced intensive care unit-acquired weakness. J Cachexia, Sarcopenia Muscle, in press

B. Chhabra, U. Granziol, M. D. Griffiths, T. Zandonai, E. Landolfi, M. Solmi, Liye Zou, P. Yang, M. B. Lichtenstein, O. Stoll, T. Akimoto, et al. Prevalence of the Risk of Exercise Addiction Based on a New Classification: A Cross-Sectional Study in 15 Countries. Int J Mental Health Addiction, in press

S. Ishibashi, N. Kamei, Y. Tsuchikawa, T. Nakamae, T. Akimoto, S. Miyaki, N. Adachi. Myelin-specific microRNA-23a/b cluster deletion inhibits myelination in the central nervous system during postnatal growth and aging. Genes, 15(4):402, 2024

2023

S. Oikawa, S. Yuan, Y. Kato, T. Akimoto. Skeletal muscle-enriched miRNAs are highly unstable in vivo and may be regulated in a Dicer-independent manner. FEBS J, 290(24), 5692-5703, 2023

J. Lee, T. Akimoto, J.S. Chang, H.S. Lee. Effects of joint mobilization combined with acupuncture on pain, physical function, and depression in stroke patients with chronic neuropathic pain: a randomized controlled trial. PLoS One, 18(8):e0281968, 2023

J. Shin, S. Miyaki, H. Asahara, T. Akimoto. MicroRNA-140 is not involved in sepsis-induced muscle atrophy. Am J Physiol Cell Physiol, 325(2):C509-C518, 2023

H. Sako, M. Youssef, O. Elisseeva, T. Akimoto, K. Suzuki, T. Ushida, T. Yamamoto. MicroRNAs slow translating ribosomes to prevent protein misfolding. EMBO J, 42(18):e112469, 2023

U. Granziol, M.D. Griffiths, L. Zou, P. Yang, H.K. Herschel, A. Junker, T. Akimoto, et al. The expanded exercise addiction inventory (EAI- 3): Towards reliable and international screening of exercise-related dysfunction. Int J Mental Health Addiction, 10, 1-27, 2023

S. Oikawa, T. Akimoto. Functional analysis of microRNAs in skeletal muscle. Methods Mol Biol, 2640:339-349, 2023

Y. Tsuchikawa, N. Kamei, Y. Sanada,T. Nakamae,T. Harada,K. Imaizumi, T. Akimoto,S. Miyaki, N. Adachi. Deficiency of microRNA-23-27-24 clusters exhibits the impairment of myelination in the central nervous system. Neural Plasticity, 2023, 8938674, 2023

Y. Fujiwara, C. Ding, Y. Sanada, D. Yimiti, M. Ishikawa, T. Nakasa, N. Kamei, K. Imaizumi, M. Lotz, T. Akimoto, S. Miyaki, N. Adachi. MiR-23a/b clusters are not essential for the pathogenesis of osteoarthritis in mouse aging and a post-traumatic models. Front Cell Dev Biol, 10:1043259, 2023

J. Lee, T. Akimoto, H.S. Lee. Effects of joint mobilization combined with traditional Korean medicine treatment on pain, physical function, and depression in stroke patients with chronic neuropathic pain. medRxiv, https://doi.org/10.1101/2023.02.06.23285552

2022

Y. Sanada, Y. Ikuta, C. Ding, M. Shinohara, Y. Dilmulati, H. Ishitobi, M. Lee, T. Akimoto, K. Nagira, S. Shibata, M. Ishikawa, T. Nakasa, K. Matsubara, M. Lotz, N. Adachi, S. Miyaki. Senescence-accelerated mice 8 (SAMP8) as a spontaneous osteoarthritis model for studies on mechanisms and interventions. Arthr Res Ther, 24: 235, 2022

T. Omoto, D. Yimiti, Y. Sanada, M. Toriyama, C. Ding, Y. Hayashi, Y. Ikuta, T. Nakasa, M. Ishikawa, M. Sano, M. Lee, T. Akimoto, C. Shukunami, S. Miyaki, N. Adachi. Tendon-specific Dicer deficient mice exhibit hypoplastic tendon through the downregulation of tendon-related genes and microRNAs. Front Cell Dev Biol, 10:898428, 2022

U. Granziol, M. Trott, T. Akimoto, et al. Cross-cultural validation of an expanded Exercise Addiction Inventory: A preliminary protocol report. PsyArXiv, 2022

2021

S. Oikawa, J. Shin, T. Akama, T. Akimoto. Dicer-mediated miRNA processing is not involved in controlling muscle mass during muscle atrophy. Sci Rep, 11(1), 19361, 2021

M. Sano, K. Morishita, S. Oikawa, T. Akimoto, K. Sumaru, Y. Kato. Live-cell imaging of microRNA expression with post-transcriptional feedback control. Mol Ther Nucleic Acids, 26, 547-556, 2021

M. Lee, J. Shin, T. Kato, K. Kanda, S. Oikawa, J. Sakuma, K. Sugama, Y. Kawakami, K. Suzuki, T. Akimoto. An acute eccentric exercise increases circulating myomesin 3 fragments. J Physiol Sci, 71, 4, 2021

M. Lee*, K. Goral*, D.J. Flis, W. Skrobot, K. Cieminski, R.A. Olek, T. Akimoto, W. Ziolkowski. Changes in urinary titin fragment in response to different types of dynamic eccentric exercises. Int J Sports Med, 42(5), 432-440, 2021

S. Schiaffino, C. Reggerni, T. Akimoto, B. Blaauw. Molecular mechanisms of skeletal muscle hypertrophy. J Neuromus Dis, 8, 169-183, 2021

2020

H. Sako, T. Akimoto, K. Suzuki, T. Ushida, T. Yamamoto. microRNA transiently pauses translating ribosomes to prevent misfolding of nascent proteins. bioRxiv, 2020

H.S. Lee, T. Akimoto, A.R. Kim. Effects of trunk extensor eccentric exercise on lipid profile and glycemic response. BMJ Open Sport Exerc Med, 6(1), e000861, 2020

S-I. Fukada, T. Akimoto, A. Sotiropoulos. Damage and manage in hypertrophic muscle: different behaviors of muscle stem cells in regenerating and hypertrophic muscle. BBA - Mol Cell Res, 1867(9):118742, 2020

2019

S. Oikawa, M. Lee, T. Akimoto. Conditional deletion of Dicer in adult mice impairs skeletal muscle regeneration. Int J Mol Sci, 20(22), 5686, 2019

M. Lee, S. Oikawa, T. Ushida, K. Suzuki, T. Akimoto. Effects of exercise training on growth and differentiation factor (GDF)11 expression in aged mice. Front Physiol, 10, 970, 2019

S. Oikawa, M. Lee, N. Motohashi, S. Maeda, T. Akimoto. An inducible knockout of Dicer in adult mice does not affect endurance exercise-induced muscle adaptation. Am J Physiol Cell Physiol, 316(2), C285-C292, 2019

M. Lee*, S. Wada*, S. Oikawa, K. Suzuki, T. Ushida, T. Akimoto. Loss of microRNA-23–27–24 clusters in skeletal muscle is not influential in skeletal muscle development and exercise-induced muscle adaptation. Sci Rep, 9(1), 1092, 2019

2018

S. Oikawa, S. Wada, M. Lee, S. Maeda, T. Akimoto. Role of endothelial microRNA-23 clusters in angiogenesis in vivo. Am J Physiol Heart Circ Physiol, 315(4), H838-H846, 2018

N. Kim, J. Kim, C.S. Yoo, K. Lim, T. Akimoto, J.H. Park. Effect of acute mid-intensity treadmill exercise on the androgen hormone level and uncoupling protein-1 expression in brown fat tissue of mouse. J Exerc Nutr Biochem, 22(1), 15-22, 2018

S. Oikawa, S. Maeda, T. Akimoto. Effect of endothelial microRNAs on blood pressure homeostasis. J Phys Fit Sports Med, 7(1), 41-45, 2018

2017

K. Kanda, J. Sakuma, T. Akimoto, Y. Kawakami, K. Suzuki. Detection of titin fragments in urine in response to exercise-induced muscle damage. PLoS One, 12(7), e0181623, 2017

W. Tsuchida, M. Iwata, T. Akimoto, S. Matsuo, Y. Asai, S. Suzuki. Heat stress modulates both anabolic and catabolic signaling pathways preventing dexamethasone-induced muscle atrophy in vitro. J Cell Physiol, 232(3), 650-664, 2017

2016

I. Moretti*, S. Ciciliot*, K. A. Dyar, R. Abraham, M. Murgia, L. Agatea, T. Akimoto, S. Bicciato, M. Forcato, P. Pierre, N. H. Uhlenhaut, P.W. J. Rigby, J. Carvajal, B. Blaauw, E. Calabria, S. Schiaffino. MRF4 negatively regulates adult skeletal muscle growth by repressing MEF2 activity. Nature Commun, 3(7), 12397, 2016

A. Onda, H. Kono, Q. Jiao, T. Akimoto, T. Miyamoto, Y. Sawada, K. Suzuki, Y. Kusakari, S. Minamisawa, T. Fukubayashi. A new mouse model of skeletal muscle atrophy using spiral wire immobilization. Muscle Nerve, 54(4), 788-791, 2016

R. Ogasawara, T. Akimoto, T. Umeno, S. Sawada, T. Hamaoka, S. Fujita. MicroRNA expression profiling in skeletal muscle reveals different regulatory patterns in high and low responders to resistance training: a pilot study. Physiol Genomics, 48(4), 320-324, 2016

2015

S. Wada, Y. Kato, S. Sawada, K. Aizawa, J. H. Park, A. P. Russell, T. Ushida, T. Akimoto. MicroRNA-23a has minimal effect on endurance exercise-induced adaptation of mouse skeletal muscle. Pflügers Archiv, 467(2), 389-398, 2015

H. Lee, M. Muthalib, T. Akimoto, K. Nosaka. Changes in the number of circulating CD34+ cells after eccentric exercise of the elbow flexors in relation to muscle damage. J Sports Health Sci, 4(3), 275–281, 2015

J. H. Park*, S. Wada*, T. Ushida, T. Akimoto. The microRNA-23a has limited roles in bone formation and homeostasis in vivo. Physiol Res, 64(5), 711-719, 2015

Y. Nakamura*, S. Miyaki*, H. Ishitobi, S. Matsuyama, T. Nakasa, N. Kamei, T. Akimoto, Y. Higashi, M. Ochi. Mesenchymal-stem-cell-derived exosomes containing microRNAs accelerate skeletal muscle regeneration. FEBS Letters, 589(11), 1257-1265, 2015

U. Agata, J. H. Park, S. Hattori, Y. Akikawa, Y. Kakutani, I. Ezawa, T. Akimoto, N. Omi. The Impact of Different Amounts of Calcium Intake on Bone Mass and Arterial Calcification in Ovariectomized Rats. J Nutr Sci Vitaminol, 61(5), 391-399, 2015

2014

S. Sawada, T. Akimoto, M. Takahashi, R. Sakurai, S. Shinkai, T. Ushida, Y. Fujiwara, K. Suzuki. Effect of aging and sex on circulating microRNAs in humans. Adv Aging Res, 3, 152-159, 2014

J. H. Park, K. Aizawa, T. Akimoto, M. Iemitsu, U. Agata, S. Maeda, K. Lim, N. Omi. DHEA administration increased trabecular mass and DHT levels in the cancellous region of the tibia in young female rats. Horm Metab Res, 46(9), 651-655, 2014

M. Kon, N. Ohiwa, A. Honda, T. Matsubayashi, T. Ikeda, T. Akimoto, Y. Suzuki, Y. Hirano, A.P. Russell. Effects of systemic hypoxia on human muscular adaptations to resistance training. Physiol Rep, 2(6), e12033, 2014

2013

T. Akimoto, K. Okuhira, K. Aizawa, S. Wada, H. Honda, T. Fukubayashi, T. Ushida. Skeletal muscle adaptation in response to mechanical stress in p130Cas-/- mice. Am J Physiol Cell Physiol, 304(6), C541-C547, 2013

U. Agata, J. H. Park, S. Hattori, Y. Iimura, T. Akimoto, N. Omi. The effect of different calcium intake on bone metabolism and arterial calcification in ovariectomized rats. J Nutri Sci Vitaminol, 59(1), 29-36, 2013

A. P. Russell, S. Lamon, H. Boon, S. Wada, I. Guller, E. L. Brown, A. V. Chibalin, J. Zierath, R. J. Snow, N. K. Stepto, G. D. Wadley, T. Akimoto. Regulation of miRNAs in human skeletal muscle following acute endurance exercise and short term endurance training. J Physiol, 591(Pt 18), 4637-4653, 2013

S. Sawada*, M. Kon*, S. Wada, T. Ushida, K. Suzuki, T. Akimoto. Profiling of circulating microRNAs after a bout of acute resistance exercise in humans. PLoS One, 8(7), e70823, 2013

S. Hattori, J. H. Park, U. Agata, T. Akimoto, M. Oda, M. Higano, Y. Aikawa Y. Nabekura, H. Yamato, I. Ezawa, N. Omi. Influence of food restriction combined with voluntary running on bone morphology and strength in male rats. Cal Tissue Int, 93(6), 540-548, 2013

2012

R. Horiuchi, T. Akimoto, Z. Hong, T. Ushida. Mechanical stretch maintains Nanog expression through PI3K/Akt signals in mouse embryonic stem cells. Exp Cell Res, 318(14), 1726-1732, 2012

A. P. Russell*, S. Wada*, L. Vergani, M. B. Hock, S. Lamon, B. Léger, T. Ushida, R. Cartoni, G. Wadley, P. Hespel, A. Kralli, G. Soraru, C. Angelini, T. Akimoto. Disruption of skeletal muscle mitochondrial network genes and miRNAs in amyotrophic lateral sclerosis. Neurobiol Dis, 49C, 107-117, 2012

D. Nakamura, T. Suzuki, M. Yasumatsu, T. Akimoto. Moderate running and plyometric training during off-season did not show significant difference on soccer-related high intensity performances compared with no training controls. J Strength Conditioning Res, 26(12), 3392-3397, 2012

2011

S. Wada, Y. Kato, M. Okutsu, S. Miyaki, K. Suzuki, Z. Yan, S. Schiaffino, H. Asahara, T. Ushida, T. Akimoto. Translational suppression of atrophic regulators by miR-23a integrates resistance to skeletal muscle atrophy. J Biol Chem, 286(44), 38456-38465, 2011

K. Shimizu, K. Aizawa, N. Suzuki, K. Masuchi, H. Okada, T. Akimoto, N. Mesaki, I. Kono, T. Akama. Influences of weight loss on monocytes and T-cell subpopulations in male judo athletes. J Strength Conditioning Res, 25(7), 1943-50, 2011

R. Yamauchi, K. Shimizu, F. Kimura, M. Takemura, K. Suzuki, T. Akama, I. Kono, T. Akimoto. Virus activation and immune function during intense training in rugby football players. Int J Sports Med, 32(5), 393-398, 2011

T. Shinada, T. Akimoto, Y. Zhu, H. Goke, I. Ohdomari. Modulation of viability of live cells by focused ion-beam exposure. Biotechnol Bioeng, 108(1), 222-225, 2011

K. Aizawa, M. Iemitsu, S. Maeda, N. Mesaki, T. Ushida, T. Akimoto. Endurance exercise training enhances local sex steroidogenesis in skeletal muscle. Med Sci Sports Exerc, 43(11), 2072-2080, 2011

J. H. Park, K. Aizawa, M. Iemitsu, K. Sato, T. Akimoto, U. Agata, S. Maeda, I. Ezawa, N. Omi. DHEA administration activates local bioactive androgen metabolism in cancellous site of tibia of ovariectomized rats. Cal Tissue Int, 89(2), 105-10, 2011

A. Onda, J. Qibin, Y. Nagano, T. Akimoto, T. Miyamoto, S. Minamisawa, T. Fukubayashi. Acupuncture ameliorated skeletal muscle atrophy induced by hindlimb suspension in mice. Biochem Biophys Res Commun, 410(3), 434-9, 2011

S. Abedelmalek, N. Souissi, T. Akimoto, S. Hadouk, Z. Tabka. Effect of acute maximal exercise on circulating levels of interleukin-12 during Ramadan fasting. Asian J Sports Med, 2(3), 154-160, 2011

2010

K. Aizawa, M. Iemitsu, S. Maeda, T. Otsuki, K. Sato, T. Ushida, N. Mesaki, T. Akimoto. Acute exercise activates local bioactive androgen metabolism in skeletal muscle. Steroid, 75(3), 219-23, 2010

M. Kon, T. Ikeda, T. Homma, T. Akimoto, Y. Suzuki, T. Kawahara. Effects of acute hypoxia on metabolic and hormonal responses to resistance exercise. Med Sci Sports Exerc, 42(7), 1279-1285, 2010

Y. Matsubara, K. Shimizu, K. Tanimura, T. Miyamoto, T. Akimoto, I. Kono. Effect of acupuncture on salivary immunoglobulin A after a bout of intense exercise. Acupunct Med, 28(1), 28-32, 2010

M. Kon, T. Iizuka, T. Maegawa, E. Hashimoto, J. Yuda, T. Aoyanagi, T. Akimoto, H. Takahashi. Salivary secretory immunoglobulin A response of elite speed skaters during a competition period. J Strength Conditioning Res, 24(8), 2249-2254, 2010

Y. Ito, N. Toriuchi, T. Yoshitaka, H. Ueno-Kudoh, T. Sato, S. Yokoyama, K. Nishida, T. Akimoto, M. Takahashi, S. Miyaki, H. Asahara. The Mohawk homeobox gene plays a critical role in tendon differentiation by regulating type I collagen production. Proc Natl Acad Sci U S A, 107(23), 10538-42, 2010

~ 2010

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